Single Family for Sale: 2275 Highway F, Defiance, MO 63341

5 beds
2 full, 2 half baths
2,815 sqft
$7,250,000
$7,250,000
2275 Highway F, Defiance, MO 63341
5 beds
2 full, 2 half baths
2,815 sqft
$7,250,000
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Price:
$7,250,000
$498,800 - 10/05/2026

Type Single Family
Style 3+ Story
Beds 5
Baths 2 full, 2 half baths
Total Living Area 2,815 sqft
Square Footage 2,815 sqft
Lot Size 105.40 acres
Year Built 1843

City Defiance
County St. Charles
School District Francis Howell R-III
Subdivision N/A

MLS 26057899
Status Active Under Contract
DOM 30 days
Imagine owning a timeless piece of Missouri history. More than 250 years ago, the Osage people traveled these valleys, and pioneers like Daniel Boone, his son Nathan and nephew/adopted son Jonathan Bryan helped shape this remarkable landscape. A captivating driveway leads around to a ONE-OF-A-KIND property built in the 1840’s for Jonathan Bryan. “Bryan Mill” rests gracefully on 105.4+/- acres providing a peaceful & tranquil atmosphere, conveniently located near Augusta & Defiance, with a STRIKING, FINELY DETAILED, FULLY FURNISHED, FRENCH INSPIRED w/exquisite imported antiques curated by Annie Brahler of EuroTrash, Inc. At the heart of the property is an 1840s built cottage exquisitely reimagined as a luxurious country residence, and STATELY early 1800’s built 68’x36’ Stone mill/outbuilding with 2 BEAUTIFUL automatic solid wood doors, floor-to-ceiling Stone fireplace, 37’+/- vaulted ceiling, kitchen, 2 half baths, & an abundant amount of storage space, AND a COMPLETELY REDONE stone chicken coop. Throughout the cottage, historic details have been carefully preserved and complemented by modern mechanical systems, conveniences, and automated security and surveillance. The home boasts 2,815+/- SqFt, 5 bedrooms, 2 full baths, with mostly original hardwood flooring throughout and a kitchen anchored by a 65 inch La Cornue Chateau Series range. The historic mill is equally remarkable. Beautifully restored and fully climate-controlled with modern HVAC systems, the mill features a catering kitchen and expansive event and entertaining spaces. It offers an extraordinary setting for private dinners, celebrations, retreats, creative pursuits, or large-scale entertaining—all without ever leaving the privacy of the estate. Create a legacy where your children and grandchildren can reconnect with nature—plant gardens, raise animals, ride horses, explore miles of side-by-side trails, or simply enjoy the peace and beauty that only a property like this can offer. Beyond the residence, private acreage unfold through rolling fields, mature woods, gardens, and majestic private pathways winding throughout the estate. A dramatic boulder firepit creates an intimate destination for evenings outdoors, while even the custom chicken coop has been thoughtfully designed to complement the architecture and character of the property. Opportunities to own a tract with this combination of history, natural beauty, privacy, and location are exceptionally rare, especially with frontage on the coveted Hwy F. This isn't just land—it's a place where your family's next chapter can begin and memories can be made for generations to come. MUST SEE! Today, you have the rare opportunity to own 105.4+/- acres of beautiful land just off Highway F, conveniently located near Augusta and Defiance, with over $1,000,000 of road and infrastructure improvements completed creating multiple opportunities for building sites on the property with electric, well and septic in place. With breathtaking ridge-top views and rolling countryside, this property is the perfect setting for a private family retreat, a picturesque mini ranch, or private equestrian estate. Create a legacy where your children and grandchildren can reconnect with nature—plant gardens, raise animals, ride horses, explore miles of side-by-side trails, or simply enjoy the peace and beauty that only a property like this can offer. *ALL PARTIES UNDERSTAND PROPERTY IS SUBJECT TO SURVEY AND APPROVED THROUGH CITY & ALL GOVERNMENTAL AUTHORITIES.* Seller will also consider dividing the property in different ways. Acreage sold SEPARATELY. See MLS #’s: 26053202 (LOT #1, 22+/- ACRES), 26053203 (LOT #2, 12.5+/- ACRES), 26053360 (LOT #3, 38.5+/- ACRES), & 26053204 (LOT #4, 32+/- ACRES).

Room Features

Basement Description Storage Space, Unfinished

Virtual Tours for 2275 Highway F Defiance, MO

Lot & Building Features

Appliances Built-In Freezer, Water Purifier, Tankless Water Heater, Built-In Refrigerator, Range Hood, Washer/Dryer, Gas Range, Disposal, Dishwasher
Architecture French Provincial, Colonial, Historic, Traditional
Construction Stone
Cooling Electric, Central Air
Heating Forced Air
Interior Decor Sound System, Smart Thermostat, Beamed Ceilings, Natural Woodwork, Center Hall Floorplan, Chandelier, Built-in Features, Recessed Lighting, Vaulted Ceiling(s), Entrance Foyer, Eat-in Kitchen
Sewer Septic Tank
Water Well
Windows And Doors Window Coverings
Fireplaces 3

Community and Schools

Elementary School Daniel Boone Elem.
Junior High School Francis Howell Middle
Senior High School Francis Howell High

Price History of 2275 Highway F, Defiance, MO

Date Name Price Difference
10/05/2026 Price Adjustment $7,250,000 6.44%
09/08/2026 Listing Price $7,748,800 N/A
*Information provided by REWS for your reference only. The accuracy of this information cannot be verified and is not guaranteed.

Map of 2275 Highway F, Defiance, MO

Location Map Street View
Photo of Roy Doskal, SRES
Roy Doskal, SRES
Owner/Broker
Direct: 314-709-2456
Office
7 Weldon Spring Heights
Weldon Spring, MO 63304
314-709-2456
Listed by Tom Shaw, REALTORS, Catherine Shaw-Connely & Thomas Shaw Jr
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2275 Highway F (MLS #26057899) is a 3+ story single family home located in Defiance, MO. This single family home is 2,815 sqft and on a lot of 4,591,224 sqft (or 105.40 acres) with 5 bedrooms and 4 baths. This property was listed on 09/08/2026 and has been priced for sale at $7,250,000.

Nearby zip codes are 63005, 63038, 63069, 63073 and 63368. This property neighbors other cities such as Dardenne Prairie, Glencoe, O Fallon, St Albans and Wildwood.

Maris

Listing Last updated . Some properties which appear for sale on this web site may subsequently have sold or may no longer be available. Walk Score map and data provided by Walk Score. Google map provided by Google. Bing map provided by Microsoft Corporation.

All information provided is deemed reliable but is not guaranteed and should be independently verified.

Listing information courtesy of: Tom Shaw, REALTORS

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